Selegiline hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

与 MAO-A (Ki = 9.06 μM) 相比，Selegiline 盐酸盐是 MAO-B (Ki = 0.091 μM) 的选择性、可逆抑制剂。单胺氧化酶 (MAO) 抑制剂可用于改善多种神经系统疾病，包括抑郁症。

Selegiline hydrochloride is a selective reversible inhibitor of MAO-B (Ki = 0.091 μM) over MAO-A (Ki = 9.06 μM). Monoamine oxidase (MAO) inhibitors have utility in ameliorating a variety of neurological conditions including depression.(In Vitro):Selegiline (1 nM-1 μM) hydrochloride inhibits recombinant human MAO-B in a concentration-dependent manner.Selegiline (10 mM) hydrochloride increases the efflux of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) from the rat hypothalamus in vitro. Selegiline hydrochloride inhibits the efflux of dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) in a dose-dependent manner.(In Vivo):Selegiline (1 mg/kg; i.p. daily for 24 days) hydrochloride reduces Cocaine self-administration of mice and does not affect Cocaine-caused body weight loss. Selegiline hydrochloride reduces 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in frontal cortex.

Selegiline (1 nM-1 μM) hydrochloride inhibits recombinant human MAO-B in a concentration-dependent manner.Selegiline (10 mM) hydrochloride increases the efflux of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) from the rat hypothalamus in vitro. Selegiline hydrochloride inhibits the efflux of dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) in a dose-dependent manner.

Selegiline (1 mg/kg; i.p. daily for 24 days) hydrochloride reduces Cocaine self-administration of mice and does not affect Cocaine-caused body weight loss. Selegiline hydrochloride reduces 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations in frontal cortex. Animal Model:Male C57BL/6J mice (20-22 g) Dosage:1 mg/kg Administration:I.p. daily for 24 days Result:Single injection did not acutely affect mouse locomotor activity.14 consecutive days administration did not affect food reward.Reduced Cocaine self-administration, and reduced DOPAC and 5-HIAA concentrations in frontal cortex.

R(-)-Deprenyl hydrochloride

Metabolic Enzyme/Protease

MAO

MAO-B

Neurological Disease

Early Parkinson's disease

14611-52-0

223.74

C13H18ClN

>98% (HPLC)

DMSO: 30 mg/mL;Water: 20 mg/mL;Ethanol: 30 mg/mL

Cl.C[C@H](Cc1ccccc1)N(C)CC#C

(2R)-N-methyl-1-phenyl-N-prop-2-ynylpropan-2-amine;hydrochloride

(-20℃)

With Ice Pack

≥ 2 years